Many radios supported including by Omni-Rig and Flrig. I use the latter.
Be aware! As with any digital communication on your radio, it is wise to run the power level at 50% or below. The PA would benefit from not being driven at the full duty cycle and save your PA.
If you have a linear amp however, you can run that at 50% to get that extra mile or two :)
As a tip, you can run two instances of Vara and configure one as transmit and one as a receive decoder.
Why not have a look on the web, Google Vara and VarAC for complete details. I suggest you (RTFM) and look at the etiquette guide.